Stem Cell Research
Hedgehog signaling maintains resident hepatic progenitors throughout life
Published in Hepatitis Weekly, June 5th, 2006
According to recent research from the United States, "Hedgehog signaling through its receptor, patched, activates transcription of genes, including Patched, that regulate the fate of various progenitors.
"Although Hedgehog signaling is required for endodermal commitment and hepatogenesis, the possibility that it regulates liver turnover in adults had not been considered because mature liver epithelial cells lack Hedgehog signaling."
"Herein, we show that this pathway is essential throughout life for maintaining hepatic progenitors. Patched-expressing cells...
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Source: Hepatitis Weekly (2006-06-05)
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