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Hepatitis Coronavirus

Hepatitis coronavirus functionally important nucleocapsid domain identified

Published in Hepatitis Weekly, June 12th, 2006

Recent research from the United States has documented the identification of functionally important negatively charged residues in the carboxy end of mouse hepatitis coronavirus A59 nucleocapsid (N) protein.

"The coronavirus N protein is a multifunctional viral gene product that encapsidates the RNA genome and also plays some as yet not fully defined role in viral RNA replication and/or transcription. A number of conserved negatively charged amino acids are located within domain III in the carboxy end of all coronavirus N proteins," wrote S. Verma and colleagues, Arizona State University.

They continued, "Previous studies suggested that the negatively...

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