Steatohepatitis

NKT lymphocytes ameliorate non-alcoholic steatohepatitis

Published in Hepatitis Weekly, June 26th, 2006

According to a study from Israel, adoptive transfer of regulatory natural killer T (NKT) lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping.

"The aim of this study was to determine the effect of adoptive transfer of regulatory (NKT) lymphocytes on the metabolic disorder in leptin-deficient ob/ob mice, which feature depletion and defective function of NKT and CD4 lymphocytes. Leptin-deficient ob/ob mice were subjected to transplantation of 1 x 10⁶ of either ob/ob or wild-type-derived NKT lymphocytes, or to transplantation of either ob/ob or wild-type-derived splenocytes,"...

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Source: Hepatitis Weekly (2006-06-26)

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