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Hepatitis C Genetics

Epigenetic silencing influences interferon resistance of HCV replicon-harboring cells

Published in Hepatitis Weekly, July 3rd, 2006

Recent research from Japan has reported that epigenetic silencing of interferon-inducible genes is implicated in interferon (IFN) resistance of hepatitis C virus (HCV) replicon-harboring cells.

"We previously established HCV replicon-harboring cell lines possessing two IFN-resistant phenotypes: a partially resistant phenotype (alpha R series) and a severely resistant phenotype (OR series)," wrote K. Naka and colleagues, Okayama University.

They continued, "We recently found that the severe IFN resistance of the OR-series cells is caused by the functional disruption of type I IFN receptors. Here, we aimed to clarify the mechanism(s) underlying the...

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