Published in Hepatitis Weekly, July 3rd, 2006
"Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IPS-1, activates IFN regulatory factor-3 (IRF-3) and the host IFN-alpha/beta response that limits virus infection. HCV NS3/4A protease cleaves IPS-1 to block RIG-I signaling, but how this regulation controls the host response to HCV is not known," wrote Y.M. Loo and colleagues, University of...
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