Published in Hepatitis Weekly, July 10th, 2006
"RNA interference (RNAi) has been proved to be a promising strategy to combat HBV infection by way of cell culture and animal model studies. In this work, esiRNAs targeting all of the four open reading frames (ORFs) of HBV genome were prepared," wrote B.Q. Xuan and colleagues, Fudan University.
"In vitro experiment showed that esiHBVP suppressed HBsAg expression most effectively. Its capacity to suppress HBV replication in vivo was then...
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