RNA Research

Intracellular-diced dsRNA silences HCV RNA and overcomes genotypic variation

Published in Hepatitis Weekly, July 10th, 2006

According to a study from Japan, intracellular-diced dsRNA has enhanced efficacy for silencing hepatitis C virus (HCV) RNA and overcomes variation in the viral genotype.

"RNA interference (RNAi) can be used to inhibit viral replication in mammalian cells and therefore could be a powerful new antiviral therapy. Small interfering RNA (siRNA) may be effective for RNAi, but there are some technical problems that must be solved in each case, for example, predicting the effective siRNA target site and targeting heterogeneous sequences in a virus population.

"We show here that diced siRNA generated from long double-stranded RNA (dsRNA) is highly effective...

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Source: Hepatitis Weekly (2006-07-10)

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