Published in Hepatitis Weekly, July 17th, 2006
"Envelope protein E2 of human HCV is an attractive component of a prototype HCV vaccine. Delivered by DNA immunogens, E2 evokes specific immune response of Th1-type, failing to induce either considerable antibody production, or T-helper cell proliferation," wrote I. Sominskaya and colleagues, Swedish Institute of Infectious Disease Control.
"We aimed at modulating the immunogenic performance of E2 gene by changing the mode of protein expression in eukaryotic cells. Plasmids were constructed encoding full-length E2 and nonstructural...
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