Hepatitis C Virus
Hepatitis C virus cleavage dissociates a complex from the mitochondrial outer membrane
Published in Hepatitis Weekly, July 31st, 2006
"Intracellular RNA virus infection is detected by the cytoplasmic RNA helicase RIG-1 that plays an essential role in signaling to the host antiviral response," wrote R.T. Lin and colleagues, McGill University.
"Recently, the adapter molecule that links RIG-1 sensing of incoming viral RNA to downstream signaling and gene activation events was characterized by four different groups; MAVS/IPS-1-1/VISA/Cardif contains an amino-terminal CARD domain and a carboxyl-terminal mitochondrial transmembrane sequence that localizes to the...
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Source: Hepatitis Weekly (2006-07-31)
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