Hepatitis D Virus

Hepatitis D antigen translocation correlates with endoplasmic reticulum stress

Published in Hepatitis Weekly, July 31st, 2006

According to recently published research from Taiwan, the induction of hepatitis D virus (HDV) large antigen (LDAg) translocation to the cytoplasm by hepatitis B virus (HBV) surface antigens (HbsAgs) correlates with endoplasmic reticulum (ER) stress and NF-kappa B activation.

"It is known that HDV requires HBV for supplying envelope proteins (HBsAgs) to produce mature virions, and the HDV LDAg is responsible for interacting with HBsAgs. However, the signal molecules involved in the cross-talk between HBsAgs and LDAg have never been reported," wrote I.C. Huang and colleagues, Chang Gung University.

"It has been previously demonstrated that the small...

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Source: Hepatitis Weekly (2006-07-31)

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