Graft-versus-Host Disease

Lymphocyte function-associated antigen-1 functions in graft-versus-host disease

Published in Hepatitis Weekly, August 7th, 2006

A study from the United States has reported that a short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of lymphocytes in graft-versus-host disease (GvHD).

"The liver is a major target organ of GvHD with massive infiltration of alloreactive lymphocytes resulting in hepatitis and hepatocyte injury.

"Although adhesive mechanisms have been implicated in the biology of GvHD hepatitis, the identity of homing receptors involved in the initial recruitment of cells from the blood is not known. We have developed a short-term homing assay in a model of murine GvHD," wrote T. Sato and...

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Source: Hepatitis Weekly (2006-08-07)

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