Hepatitis C Virus

Hammerhead ribozymes display significant anti-hepatitis C viral effect

Published in Hepatitis Weekly, August 7th, 2006

According to a study from Germany, hammerhead ribozymes (Rz) with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells.

"Four different ribozymes targeting the hepatitis C virus (HCV) 5'-non-coding region (NCR) at nucleotide (nt) positions GUA 165 (Rz1), GUC 270 (Rz2), GUA 330 (Rz3) and GCA 348 (Rz1293) were compared for in vitro cleavage using a 455 nt HCV RNA substrate," wrote M.A. Gonzalez-Carmona and colleagues, Bavarian State Ministry of the Environment.

"The GUA 330 (Rz3) and GCA 348 (Rz1293) ribozymes, both targeting the HCV loop IV region, were found to...

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Source: Hepatitis Weekly (2006-08-07)

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