Neuroprotection
Valproic acid prevents brain injury in canine model of hypothermic circulatory arrest
Published in Hepatitis Weekly, August 7th, 2006
According to recent research from the United States, "The anticonvulsant valproic acid (sodium valproate, Depacon) acts as a neuroprotectant in rodents, but has never been tested in larger animals. We used valproate in our canine model of hypothermic circulatory arrest to evaluate its neuroprotective benefit in complex cardiac surgical cases."
"Thirteen dogs pretreated with valproate before two hours of hypothermic circulatory arrest survived for 24 hours (n=7) or 72 hours (n=6)," reported Jason A. Williams and colleagues at Johns Hopkins University. "Thirteen...
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Source: Hepatitis Weekly (2006-08-07)
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