Hepatitis B Virus

Hepatitis B virus capsid-like particles stimulate protective antibody responses

Published in Hepatitis Weekly, August 14th, 2006

According to recently published research from Germany, hepatitis B virus (HBV) capsid-like particles (CLPs) can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection.

"HBV CLPs, icosahedral assemblies formed by 90 or 120 core protein dimers, hold promise as immune-enhancing vaccine carriers for heterologous antigens. Insertions into the immunodominant c/e1B cell epitope, a surface-exposed loop, are especially immunogenic.

"However, display of whole proteins, desirable to induce multispecific and possibly neutralizing antibody responses, can be...

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Source: Hepatitis Weekly (2006-08-14)

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