Encephalitis

Virus-specific CD4 T cells are pathogenic in acute encephalitis

Published in Hepatitis Weekly, August 21st, 2006

According to recently published research from the United States, virus-specific CD4 T cells are pathogenic in coronavirus-induced acute encephalitis.

"Acute viral encephalitis is believed to result from direct virus destruction of infected cells and from virus-induced host immune response, but the relative contribution of each remains largely unknown. For example, C57BL/6 (116) mice infected with mouse hepatitis virus (JHM strain, JHMV) develop severe encephalitis, with death occurring within 7 days.

"Here, we show that the host response to a single JHMV-specific immunodominant CD4 T-cell epitope is critical for severe disease," wrote D. Anghelina...

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Source: Hepatitis Weekly (2006-08-21)

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