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Hepatitis B Virus

Polymorphisms affect hepatitis B virus clearance and hepatocellular carcinoma

Published in Hepatitis Weekly, August 21st, 2006

According to a study from South Korea, IGF2 polymorphisms are associated with hepatitis B virus (HBV) clearance and hepatocellular carcinoma (HCC).

"The aim of this study was to determine whether IGF2 polymorphisms are associated with the clearance of HBV infection and the risk of HCC. A total of 1095 Korean subjects were prospectively enrolled in this case-control study," wrote Y.J. Kim and colleagues, Seoul National University.

"The rates of IGF2 polymorphisms were determined in each group. The IGF2 + 820E allele (IGF2 + 820G/G) and the IGF2 + 6815A/A genotype were strongly associated with the resolution of HBV infection (OR=.62-.73; p=.001-.03 and...

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