Hepatitis B Virus

Chronic hepatitis B suppressed viral rebound correlates with T cell responses

Published in Hepatitis Weekly, August 28th, 2006

According to a study from South Korea, chronic hepatitis B (CHB) suppressed viral rebound correlates with antiviral T-cell responses.

"Despite recent advances in the chemotherapy of CHB, an effective viral suppression after cessation of therapy has not yet been achieved. To investigate whether hepatitis B virus (HBV)-specific T-cell responses are inducible and can contribute to the viral suppression after cessation of the therapy, we conducted a proof-of-concept study with a DNA vaccine comprising of most HBV genes plus genetically engineered interleukin-12 DNA (IL-12N222L) in 12 CHB carriers being treated with lamivudine (LAM)," wrote S.H. Yang and colleagues, Pohang...

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Source: Hepatitis Weekly (2006-08-28)

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