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Hepatosteatosis & Hepatitis

Hepatosteatosis T helper response is associated with enhanced mediated hepatitis

Published in Hepatitis Weekly, August 28th, 2006

According to a study from the United States, favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis.

"Steatohepatitis enhances the severity of liver injury caused by acute inflammation. The purpose of this study was to test the hypothesis that fatty liver due to chronic Cho-deficient diet exacerbates concanavalinA (conA)-induced liver hepatitis, which is predominantly facilitated by T cells," wrote M. Kremer and colleagues, University of North Carolina.

"Male C57BL/6 mice were fed either control Cho-sufficient diet (CSD) or Cho-deficient diet (CDD) for 6 weeks before ConA administration....

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