Hepatitis B Virus

Reports from Germany, Italy and France describe recent advances in hepatitis B virus research

Published in Hepatitis Weekly, September 4th, 2006

Data on hepatitis B virus are outlined in reports from Germany, Italy and France.

Study 1: A recent study from Germany has chronicled the interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus (HBV) replication.

"Hypermutations in HBV DNA by APOBEC3 cytidine deaminases have been detected in vitro and in vivo, and APOBEC3G (A3G) and A-POBEC3F (A3F) have been shown to inhibit the replication of HBV in vitro, but the presumably low or even absent hepatic expression of these enzymes has raised the question as to their physiological impact on HBV replication. We show that normal human liver...

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Source: Hepatitis Weekly (2006-09-04)

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