Hepatitis B Virus

Hepatitis B surface antigen chimeric antibody generated

Published in Hepatitis Weekly, September 25th, 2006

Recent research from India has reported on the generation and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen (HbsAg).

"Antibody against HBsAg is used for passive immunotherapy in certain cases of hepatitis B infection. The authors have earlier reported a high-affinity mouse monoclonal (5S) against HbsAg. However, this mouse antibody cannot be used for therapeutic purposes because it may elicit antimouse immune responses," wrote B. Bose and colleagues, All India Institute of Medical Science.

"Chimerization by replacing mouse constant domains with human ones can reduce the immunogenicity of this...

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Source: Hepatitis Weekly (2006-09-25)

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