Published in Hepatitis Weekly, September 25th, 2006
"Antibody against HBsAg is used for passive immunotherapy in certain cases of hepatitis B infection. The authors have earlier reported a high-affinity mouse monoclonal (5S) against HbsAg. However, this mouse antibody cannot be used for therapeutic purposes because it may elicit antimouse immune responses," wrote B. Bose and colleagues, All India Institute of Medical Science.
"Chimerization by replacing mouse constant domains with human ones can reduce the immunogenicity of this...
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