Hepatitis C Virus
Hepatitis C virus core protein targeting to lipid droplets clarified
Published in Hepatitis Weekly, September 25th, 2006
"HCV core protein is targeted to lipid droplets, which serve as intracellular storage organelles, by its C-terminal domain, termed D2. From circular dichroism and nuclear magnetic resonance analyses, we demonstrate that the major structural elements within D2 consist of two amphipathic alpha-helices (Helix I and Helix II) separated by a hydrophobic loop," wrote S. Boulant and colleagues, CNRS.
"Both helices require a hydrophobic environment for folding, indicating that lipid interactions contribute to their...
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Source: Hepatitis Weekly (2006-09-25)
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