Published in Hepatitis Weekly, September 25th, 2006
"HCV core protein is targeted to lipid droplets, which serve as intracellular storage organelles, by its C-terminal domain, termed D2. From circular dichroism and nuclear magnetic resonance analyses, we demonstrate that the major structural elements within D2 consist of two amphipathic alpha-helices (Helix I and Helix II) separated by a hydrophobic loop," wrote S. Boulant and colleagues, CNRS.
"Both helices require a hydrophobic environment for folding, indicating that lipid interactions contribute to their...
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