Apoptosis

Hepatoma cell apoptosis inhibited by hepatitis C virus non-structural protein

Published in Hepatitis Weekly, October 9th, 2006

According to recent research from the People's Republic of China published in the journal FEBS Letters, hepatitis C virus (HCV) non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells.

"HCV non-structural protein NS5A plays an important role in viral replication and various cellular events. To gain further insight into the function of NS5A, we screened a human fetal liver cDNA library for its interacting proteins using the yeast two-hybrid system," wrote J.D. Wang and colleagues, Fudan University.

"FKBP38, a 38 kDa immunosuppressant FK506-binding protein, was identified and its interaction with NS5A was...

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Source: Hepatitis Weekly (2006-10-09)

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