Hepatitis C Virus

Reports from the United States and Turkey advance knowledge in hepatitis C virus research

Published in Hepatitis Weekly, October 9th, 2006

Reports from the United States and Turkey highlight recent research in hepatitis C virus.

Study 1: According to recent research from the United States, hepatitis C virus (HCV) proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells.

"Hepatitis C infection induces hepatic oxidative stress. HO, the rate-controlling enzyme of heme catabolism, plays a key role as a protector against oxidative, and other stresses.

"Other recent work has implicated Bach1, a heme binding protein that represses gene expression, in the regulation of HO-1 gene expression. We investigated the effects...

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Source: Hepatitis Weekly (2006-10-09)

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