Published in Hepatitis Weekly, October 16th, 2006
"The RNA-dependent RNA polymerase of the hepatitis C virus and the BVDV is able to initiate RNA synthesis de novo in the absence of a primer. Previous crystallographic data have pointed to the existence of a GTP-specific binding site (G-site) that is located in the vicinity of the active site of the BVDV enzyme.
"Here we have studied the functional role of the G-site and present evidence to show that specific GTP...
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