Hepatitis B Virus

DNA-encoding hepatitis B virus core antigen enhances CD8 T cell longevity

Published in Hepatitis Weekly, October 23rd, 2006

In a recent report published in the World Journal of Gastroenterology, researchers in the People's Republic of China documented that coimmunization with interleukin-15 (IL-15) plasmid enhances the longevity of CD8 T cells induced by DNA encoding hepatitis B virus core antigen.

W. Zhang and colleagues, Fudan University, wrote that the study was done "to test the feasibility of delivering a plasmid encoding IL-15 as a DNA vaccine adjuvant for improving the immune responses induced by hepatitis B virus core gene DNA vaccine."

"We used RT-PCR based strategies to develop IL-15 expression constructs. We first confirmed that the gene could be...

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Source: Hepatitis Weekly (2006-10-23)

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