Apoptosis

Hepatocyte apoptosis induction by hepatitis B virus produces different effects

Published in Hepatitis Weekly, October 23rd, 2006

A study from Germany has reported on the differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein (HBx).

"HBx has been shown to be weakly oncogenic in vitro. The transforming activities of HBx have been linked with the inhibition of several functions of the tumor suppressor p53. We have studied whether HBx may have different effects on p53 depending on the cell type," wrote N. Fiedler and colleagues, University of Rostock.

"We used the human hepatoma cell line HepG2 and the immortalized murine hepatocyte line AML12 and analyzed stably transfected clones which expressed physiological amounts...

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Source: Hepatitis Weekly (2006-10-23)

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