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Hepatitis B Virus

Hepatitis B virus genotype response to long-term lamivudine treatment clarified

Published in Hepatitis Weekly, October 30th, 2006

Recent research from Japan published in the Journal of Medical Virology has chronicled the response to long-term lamivudine treatment in patients infected with hepatitis B virus (HBV) genotypes A, B, and C.

"Response to lamivudine treatment longer than 1 year was compared in 15 patients persistently infected with HBV genotype A, 38 with genotype B, and 449 with genotype C," wrote M. Kobayashi and colleagues, Toranomon General Hospital.

"Patients with genotype A were younger (median age 37 [range 24-49] vs. 47 [24-67] or 44 [18-73], p=.015), possessed hepatitis B e antigen (HBeAg) more frequently (73% vs. 21% or 56%, p<.001) and HBV DNA in...

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