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Hepatitis C Virus

Findings from University of Manchester, Faculty of Life Sciences provide new insights into hepatitis c virus

Published in Hepatitis Weekly, November 6th, 2006

Investigators publish new data in the report "Cap-dependent and hepatitis C virus internal ribosome entry site-mediated translation are modulated by phosphorylation of eIF2alpha under oxidative stress." According to recent research from Manchester, the United Kingdom, "Chronic hepatitis C is often associated with oxidative stress. Hepatitis C virus (HCV) utilizes an internal ribosome entry site (IRES) element for translation, in contrast to cap-dependent translation of the majority of cellular proteins."

"To understand how virus translation is modulated under oxidative stress, HCV IRES-mediated translation was compared with cap-dependent translation using a bicistronic...

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