Hepatitis C Virus
High-affinity hepatitis C polymerase aptamers display genotypic specificity
Published in Hepatitis Weekly, November 6th, 2006
"Research into antiviral agents directed at HCV proteins is commonly based and tested on a single genotype, namely, genotype 1. This is despite the high level of variability of the RNA virus and the frequency of infection with genotypes other than genotype 1.
"The systematic evolution of ligands by exponential enrichment (SELEX) is a novel in vitro approach used in this study that allows rapid screening of vast nucleic acid libraries to isolate sequences (termed aptamers) that bind to target proteins with...
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Source: Hepatitis Weekly (2006-11-06)
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