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Hepatitis Genetics

Research from Tokyo Metropolitan Institute of Gerontology broadens understanding of hepatitis genetics

Published in Hepatitis Weekly, November 13th, 2006

Scientists discuss in "CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice" new findings in hepatitis. "Elevated hepatic reactive oxygen species play an important role in pathogenesis of liver diseases, such as alcohol-induced liver injury, hepatitis C virus infection, and nonalcoholic steatohepatitis. In the present study, we investigated and compared the hepatic lipid metabolisms of liver-specific Sod2 (superoxide dismutase 2) knock-out (Sod2 KO), Sod1 knock-out (Sod1 KO), and Sod1/liver-specific Sod2 double knock-out mice (double KO)," scientists writing in the Journal of Biological Chemistry report.

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