Reports outline hepatitis c virus study findings from Osaka University, Department of Molecular Virology

Scientists discuss in "Oligomerization of hepatitis C virus core protein is crucial for interaction with the cytoplasmic domain of e1 envelope protein" new findings in hepatitis C virus . "Hepatitis C virus (HCV) contains two membrane-associated envelope glycoproteins, E1 and E2, which assemble as a heterodimer in the endoplasmic reticulum (ER). In this study, predictive algorithms and genetic analyses of deletion mutants and glycosylation site variants of the E1 glycoprotein were used to suggest that the glycoprotein can adopt two topologies in the ER membrane: the conventional type I membrane topology and a polytopic topology in which the protein...

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