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Hepatitis B Virus

Researchers at Squibb Pharmaceutical Research Institute release new data on hepatitis b virus

Published in Hepatitis Weekly, December 25th, 2006

Scientists discuss in "Entecavir resistance is rare in nucleoside naïve patients with hepatitis B" new findings in hepatitis B virus. "Comprehensive monitoring of genotypic and phenotypic antiviral resistance was performed on 673 entecavir (ETV)-treated nucleoside naïve hepatitis B virus (HBV) patients. ETV reduced HBV DNA levels to undetectable by PCR (<300 copies/mL, <57 IU/mL) in 91% of hepatitis B e antigen (HBeAg)-positive and -negative patients by Week 96," investigators in the United States report.

"Thirteen percent (n=88) of the comparator lamivudine (LVD)-treated patients experienced a virologic rebound (>or=1 log increase from nadir by PCR) in the...

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