Hepatitis B Virus Genetics
Investigators at University of Buenos Aires have published new data on hepatitis b virus genetics
Published in Hepatitis Weekly, February 5th, 2007
New investigation results, "Intrahost evolution of HBe antigen-negative hepatitis B virus genomes ascribed to the F genotype: a longitudinal 3 year retrospective study," are detailed in a study published in The Journal of General Virology. "The intrahost hepatitis B virus (HBV) genomic evolution process of an HBe antigen (HBeAg)-negative chronic HBV patient (designated RI) was studied. Two nearly full-length direct sequences obtained in 1995 (RI95) and 1998 (RI98) showed: (a) a mutation rate of 2.7x10(-3) nucleotides per site per year; (b) nucleotide changes mainly located at single coding regions (p=0.002); (c) mixed populations; and (d) a predominance of non-synonymous substitutions...
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Source: Hepatitis Weekly (2007-02-05)
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