Hepatitis B Virus Gene Therapy
Studies from Institute of Biomedical Science describe new findings in hepatitis B virus gene therapy
Published in Hepatitis Weekly, February 12th, 2007
Current study results from the report, "Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA," have been published. "RNA interference (RNAi) was reported to block hepatitis B virus (HBV) gene expression and replication in vitro and in vivo. However, it remains a technical challenge for RNAi-based therapy to achieve long-term and complete inhibition effects in chronic HBV infection, which presumably requires more extensive and uniform transduction of the whole infected hepatocytes," researchers in Taipei, Taiwan report.
"To increase the in vivo transfection efficiency in liver, we used a...
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Source: Hepatitis Weekly (2007-02-12)
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