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Hepatitis C Virus

Data on hepatitis C virus detailed by researchers at New York Medical College

Published in Hepatitis Weekly, February 19th, 2007

Researchers detail in "Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: magnesium provides a bridge for ATP to fuel unwinding," new data in hepatitis C virus. According to recent research published in the journal JMB Online, "This study investigates the role of magnesium ions in coupling ATP hydrolysis to the nucleic acid unwinding catalyzed by the NS3 protein encoded by the hepatitis C virus (HCV). Analyses of steady-state ATP hydrolysis rates at various RNA and magnesium concentrations were used to determine values for the 15 dissociation constants describing the formation of a productive enzyme-metal-ATP-RNA complex and the four...

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