Hepatitis

Researchers from University of Mainz provide details of new studies and findings in the area of hepatitis

Published in Hepatitis Weekly, February 19th, 2007

A new study, "IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet," is now available. "T-cell-mediated fulminant hepatitis is a potentially life-threatening event for which the underlying pathogenic mechanisms are not fully understood. Here, we demonstrate a key regulatory role of IL-28A in T-cell-mediated hepatitis," scientists in Mainz, Germany report.

"We cloned the murine IL-28A gene by reverse-transcription polymerase chain reaction, assessed the effects of recombinant IL-28A, and generated IL-28A-transgenic mice. IL-28A induced TH1 cytokine production by CD4+ T lymphocytes in a T-bet-dependent manner and was...

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Source: Hepatitis Weekly (2007-02-19)

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