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Hepatitis Immunology

Scientists at Osaka City University publish new data on hepatitis immunology

Published in Hepatitis Weekly, March 19th, 2007

Fresh data on hepatitis are presented in the report "Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases. Thiopurine S-methyltransferase (TPMT) genotypes or phenotypes may be a predictive factor for azathioprine-induced toxicities. We investigated the genotypic status of TPMT to evaluate the risk of azathioprine-related adverse effects in Japanese patients with different liver diseases, including autoimmune hepatitis (AIH)," scientists writing in the journal Liver International report.

"49 patients with AIH, 67 with primary biliary cirrhosis (PBC), and 120 with hepatitis C virus (HCV) were examined. TPMT genotypes...

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