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HIV/AIDS

Selection of an HIV Variant in a Patient Co-infected with HIV and HBV during Baraclude (entecavir) treatment

Published in Hepatitis Weekly, March 19th, 2007

A case report has been received in which the selection of a human immunodeficiency virus (HIV) variant containing the M184V resistance substitution was documented during Baraclude(R) (entecavir) treatment for chronic hepatitis B virus (HBV) infection in an HIV/HBV co-infected patient who was not simultaneously receiving highly active anti-retroviral therapy (HAART). Current treatment guidelines recommend Baraclude as an option for treatment of HBV in the HIV/HBV co-infected adult patient who does not qualify for HAART, however, in light of the newly reported case history provided, Bristol-Myers Squibb advises caution if Baraclude is used in this setting.

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