Hepatitis B Virus
Findings from Wuhan University, College of Life Sciences broaden understanding of hepatitis B virus
Published in Hepatitis Weekly, April 16th, 2007
Research findings, "Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response," are discussed in a new report. "Numerous viruses including hepatitis B virus (HBV) induce endoplasmic reticulum (ER) stress, which interrupts protein folding causing accumulation of unfolded or misfolded proteins in ER. To alleviate the stress placed on ER, these proteins must be refolded or degraded by activating a specific cellular response known as ER stress response or unfolded protein response (UPR)," scientists in Wuhan, People's Republic of China report.
"Two UPR-specific signaling pathways involving transmembrane proteins ATF6 and XBP1...
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Source: Hepatitis Weekly (2007-04-16)
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