Gene Therapy
Researchers at Chinese Academy of Sciences publish new data on gene therapy
Published in Hepatitis Weekly, April 30th, 2007
New research, "Enhancing the potency of HBV DNA vaccines using fusion genes of HBV-specific antigens and the N-terminal fragment of gp96," is the subject of a report. According to recent research from Beijing, People's Republic of China, "Many clinical trials show that DNA vaccine potency needs to be greatly enhanced. We have reported that the N-terminal fragment of glycoprotein 96 (gp96) is able to produce an adjuvant effect for production of cytotoxic T-lymphocytes (CTLs) with hepatitis B virus (HBV)-specific peptides."
"Here, we report a new strategy for HBV DNA vaccine design using a partial gp96 sequence. We linked the N-terminal 1-355aa (N355) of gp96 to HBV genes...
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Source: Hepatitis Weekly (2007-04-30)
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