Chemistry
Study results from Uppsala University, Department of Medicinal Chemistry update understanding of chemistry
Published in Hepatitis Weekly, June 25th, 2007
Research findings, "Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors," are discussed in a new report. According to a study from Uppsala, Sweden, "There is an urgent need for more efficient therapies for people infected with hepatitis C virus (HCV). HCV NS3 protease inhibitors have shown proof-of-concept in clinical trials, which make the virally encoded NS3 protease an attractive drug target."
"Product-based NS3 protease inhibitors comprising a P1 C-terminal carboxylic acid have shown to be effective and we were interested in finding alternatives to this crucial carboxylic acid group. Thus, a series of...
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Source: Hepatitis Weekly (2007-06-25)
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