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Hepatitis C Virus
Findings from National Taiwan University, Institute of Microbiology advance knowledge in hepatitis C virus
August 6th, 2007
Current study results from the report, "Differential requirements of NS4A for internal NS3 cleavage and polyprotein processing of hepatitis C virus," have been published. According to a study from Taipei, Taiwan, "The NS3 protein of hepatitis C virus (HCV) possesses protease activity responsible for the proteolytic cleavage of the viral polyprotein at the junctions of nonstructural proteins downstream of NS3. The NS3 protein was also found to be internally cleaved." "In this study, we demonstrated that internal cleavages occurred on the NS3 protein of genotype 1b in the presence of NS4A, both in culture cells and with a mouse model system. No internal cleavage products...
Source: Hepatitis Weekly (2007-08-06)
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