Hepatitis Weekly
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Hepatitis C Virus Genetics
Researchers from National Institute of Infectious Disease, Infectious Diseases Department detail new studies and findings in the area of hepatitis C virus genetics
August 6th, 2007
New research, "The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells," is the subject of a report. "The JFH-1 strain of hepatitis C virus (HCV) is a genotype 2a strain that can replicate autonomously in Huh7 cells. The J6 strain is also a genotype 2a strain, but its full genomic RNA does not replicate in Huh7 cells," scientists in Shinjuku, Japan report. "However, chimeric J6/JFH-1 RNA that has J6 structural-protein-coding regions and JFH-1 nonstructural-protein-coding regions can replicate autonomously and produce infectious HCV particles. In order to determine the mechanisms underlying JFH-1 RNA...
Source: Hepatitis Weekly (2007-08-06)
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