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Hepatitis

Study data from Erasmus University update knowledge of hepatitis

Published in Hepatitis Weekly, September 24th, 2007

"Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle," scientists writing in the Virology Journal report.

"Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production," wrote M. Raaben and colleagues, Erasmus University.

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