Hepatitis B Virus

Reports outline hepatitis b virus study findings from E.D. Ugo and colleagues

Published in Hepatitis Weekly, September 24th, 2007

In this recent study, researchers in Rome, Italy conducted a study "To determine whether the addition of a pre-S/S human vaccine increases the antiviral activity of lamivudine, four woodchucks were treated with a daily dose of 100 mg/kg lamivudine and four 50 p,g doses of CHO-derived pre-S/S human vaccine. WHV DNA titres decreased up to two logarithms in three woodchucks."

"At week 4, in three of the animals, the sequence analysis showed a predominant strain containing a nucleotide change from A to T at position 1696 of domain B of the WHV DNA polymerase. Vaccination did not further suppress WHV DNA, despite anti-HBs production in three animals," wrote E.D. Ugo and...

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Source: Hepatitis Weekly (2007-09-24)

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