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Hepatitis B Virus Therapy

Findings from Thomas Jefferson University broaden understanding of hepatitis B virus therapy

Published in Hepatitis Weekly, October 8th, 2007

Research findings, 'Baseline HBV DNA level is the most important factor associated with virologic breakthrough in chronic hepatitis B treated with lamivudine,' are discussed in a new report. In this recently published article, scientists in the United States conducted a study "To identify the factors associated with virologic breakthrough and to select a subgroup of patients who respond well to lamivudine without developing virologic breakthrough (VBT). Of 79 patients who had received lamivudine therapy for 9-57 mo, 34 were HBeAg-positive and 45 were HBeAg-negative, 24 developed virologic breakthrough and 55 did not."

"Clinical and virologic factors were compared...

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