Hepatitis C Virus

Reports from Stanford University add new data to research in hepatitis C virus

Published in Hepatitis Weekly, October 29th, 2007

Research findings, 'A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication,' are discussed in a new report. According to recent research published in the Journal of Virology, "'Hepatitis C virus (HCV) is an important cause of liver disease worldwide. Current therapies are inadequate for most patients."

"Using a two-hybrid screen, we isolated a novel cellular binding partner interacting with the N terminus of HCV nonstructural protein NS5A. This partner contains a TBC Rab-GAP (GTPase-activating protein) homology domain found in all known Rab-activating proteins. As the first described interaction between such a Rab-GAP and a viral...

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Source: Hepatitis Weekly (2007-10-29)

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