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Hepatitis C Virus

Recent studies from University of Texas add new data to hepatitis C virus

Published in Hepatitis Weekly, November 5th, 2007

"Many viruses have evolved mechanisms to alter mitochondrial function. The hepatitis C virus (HCV) produces a viral core protein that targets to mitochondria and increases Ca2(+)- dependent ROS production," scientists in the United States report.

"The aim of this study was to determine whether core's effects are mediated by changes in mitochondrial Ca2+ uptake. Core expression caused enhanced mitochondrial Ca2+ uptake in response to ER Ca2+ release induced by thapsigargin or ATP. It also increased mitochondrial superoxide production and mitochondrial permeability transition ( MPT). Incubating mouse liver mitochondria with an HCV core ( 100 ng/mg) in vitro increased Ca2+...

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