Hepatitis B Virus

Study results from Y.C. Chou et al provide new insights into hepatitis B virus

Published in Hepatitis Weekly, November 19th, 2007

According to a study from Taiwan, "Transforming growth factor-betal (TGF-beta 1) is a pleiotropic cytokine with pivotal roles in the regulation of cellular functions and immune responses. In this study, we found that TGF-beta 1 was able to effectively suppress hepatitis B virus (HBV) replication."

"In the presence of TGF-beta 1, the level of viral replicative intermediates was dramatically decreased, both in actively dividing cells and in confluent cells. At the same time, the levels of viral transcripts, core protein, and nucleocapsid were significantly diminished by TGF-beta 1 treatment. Interestingly, the inhibitory activity of TGF-beta 1 was associated with...

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Source: Hepatitis Weekly (2007-11-19)

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