Tuberculosis

Research reports on tuberculosis from H.J. Cho and colleagues provide new insights

Published in Hepatitis Weekly, January 21st, 2008

According to a study from Seoul, South Korea, "Antituberculosis drug-induced hepatitis attributed to isoniazid (INH) is one of the most prevalent drug-induced liver injuries. INH is metabolized by hepatic N-acetyltransferase (NAT) and cytochrorne P450 2E1 (CYP2E1) to form hepatotoxins."

"The aim of this study was to evaluate whether polymorphisms of the NAT2 and/or CYP2E1 genes were associated with antituberculosis drug-induced hepatotoxicity in Korean patients. A total of 132 patients with tuberculosis who received antituberculosis treatment were followed prospectively. Their NAT2 and CYP2E1 genotypes were determined using polymerase chain reaction (PCR) with or...

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Source: Hepatitis Weekly (2008-01-21)

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